By Terry Wikle Shapiro
Stem mobile and Bone Marrow Transplantation
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Extra resources for A Clinical Guide to Stem Cell and Bone Marrow Transplantation
3. The rationale for this approach derived from settings other than BMT, where combinations of cytotoxic drugs had been shown to be more effective than single agents. 4. The use of a combination of agents allowed for dose escalation without significant overlap in toxicity.
Conditioning regimens using single-agent chemotherapy combined with total body irradiation (TBI) 1. Early preparative regimens contained TBI as the only primary method used in patients undergoing BMT for hematologic malignancies. 1 2. This approach was based on the initial findings demonstrating that BMTs could salvage animals that were accidentally exposed to lethal doses of radiation. 3. Radiation therapy is used as a cell cycle specific antitumor therapy. 4. Cyclophosphamide was added to radiation therapy because it was found to be an effective cytotoxic approach and appeared to have few nonhematopoietic toxicities that overlapped with TBI.
2. , Gaucher's disease). b) Allogeneic BMT is effective in the transfer of enzymes from the enzymatically normal, bone marrow-derived cells to deficient cells by direct cell-to-cell contact. c) BMT may be effective through the release of enzymes into plasma, as may occur with the disintegration of donor-derived WBCs. Subsequently, the circulating enzymes may be taken up by enzymatically deficient cells. d) The presence of a concentration gradient of storage product between the tissues and the plasma compartment may result from the breakdown of circulating substrate by the lysosomal enzymes present in WBCs and tissue macrophages of donor origin and give rise to clearance of the storage product.
A Clinical Guide to Stem Cell and Bone Marrow Transplantation by Terry Wikle Shapiro